3-(4-Piperidinyl)-1H-indole → 3-(difluoromethyl)-6-[4-(1H-indol-3-yl)piperidin-1-yl][1,2,4]triazolo[4,3-b]pyridazine

HRID 1674984Notes

Reaction equation

HRID 1674984 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH:8]=2)[CH2:3][CH2:2]1.[F:16][CH:17]([F:33])[C:18]1[N:22]2[N:23]=[C:24](N3CCNCC3)[CH:25]=[CH:26][C:21]2=[N:20][N:19]=1>>[F:33][CH:17]([F:16])[C:18]1[N:22]2[N:23]=[C:24]([N:1]3[CH2:6][CH2:5][CH:4]([C:7]4[C:15]5[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=5)[NH:9][CH:8]=4)[CH2:3][CH2:2]3)[CH:25]=[CH:26][C:21]2=[N:20][N:19]=1

Participants

3

Reactant 2

HCID 7022353-(4-Piperidinyl)-1H-indoleHCID 673418813-(Difluoromethyl)-6-(piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine

Product 1

HCID 591497113-(difluoromethyl)-6-[4-(1H-indol-3-yl)piperidin-1-yl][1,2,4]triazolo[4,3-b]pyridazineYield 85%

Procedure

A mixture of 3-(piperidin-4-yl)-1H-indole and 3-(difluoromethyl)-6-(piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 216 to give 3-(difluoromethyl)-6-[4-(1H-indol-3-yl)piperidin-1-yl][1,2,4]triazolo[4,3-b]pyridazine in 85% yield.

Workup

  1. customto react by an analogous method to Example 216

Sources & evidence

ORD record
ord-a750de7203e14ad7b64fa7baa3502189
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

Loading…