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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1674984Generated: November 3, 2026

3-(4-Piperidinyl)-1H-indole → 3-(difluoromethyl)-6-[4-(1H-indol-3-yl)piperidin-1-yl][1,2,4]triazolo[4,3-b]pyridazine

https://huagongshe.com/reaction/1674984

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4-Piperidinyl)-1H-indoleHCID 702235—
Reactant3-(Difluoromethyl)-6-(piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazineHCID 67341881—
Product3-(difluoromethyl)-6-[4-(1H-indol-3-yl)piperidin-1-yl][1,2,4]triazolo[4,3-b]pyridazineHCID 5914971185%

Reaction Steps

A mixture of 3-(piperidin-4-yl)-1H-indole and 3-(difluoromethyl)-6-(piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 216 to give 3-(difluoromethyl)-6-[4-(1H-indol-3-yl)piperidin-1-yl][1,2,4]triazolo[4,3-b]pyridazine in 85% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08003649B2
Source datasetuspto-grants-2011_08
ORD IDord-a750de7203e14ad7b64fa7baa3502189
Source noteuspto-grants-2011_08