6-Chloro-3-(difluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine → HCID 59149840, compound

HRID 1674986Notes

Reaction equation

HRID 1674986 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH3:9])=[CH:4][CH:3]=1.Cl[C:17]1[CH:18]=[CH:19][C:20]2[N:21]([C:23]([CH:26]([F:28])[F:27])=[N:24][N:25]=2)[N:22]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([N:10]2[CH2:11][CH2:12][N:13]([C:17]3[CH:18]=[CH:19][C:20]4[N:21]([C:23]([CH:26]([F:27])[F:28])=[N:24][N:25]=4)[N:22]=3)[CH2:14][CH2:15]2)[CH3:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14723856-Chloro-3-(difluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazineHCID 28798584HCID 28798584, compound

Product 1

HCID 59149840HCID 59149840, compoundYield 75%

Procedure

A mixture of (R)-1-[1-(4-bromophenyl)ethyl]piperazine and 6-chloro-3-difluoromethyl-[1,2,4]-triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 269 to give 6-[4-[(1R)-1-(4-bromophenyl)ethyl]piperazin-1-yl]-3-(difluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine in 75% yield.

Workup

  1. customto react by an analogous method to Example 269

Sources & evidence

ORD record
ord-f876a9ef4e1844e2a54e2ae15ce21644
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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