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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1674986Generated: October 31, 2026

6-Chloro-3-(difluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine → HCID 59149840, compound

https://huagongshe.com/reaction/1674986

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Chloro-3-(difluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazineHCID 1472385—
ReactantHCID 28798584HCID 28798584—
ProductHCID 59149840HCID 5914984075%

Reaction Steps

A mixture of (R)-1-[1-(4-bromophenyl)ethyl]piperazine and 6-chloro-3-difluoromethyl-[1,2,4]-triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 269 to give 6-[4-[(1R)-1-(4-bromophenyl)ethyl]piperazin-1-yl]-3-(difluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine in 75% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08003649B2
Source datasetuspto-grants-2011_08
ORD IDord-f876a9ef4e1844e2a54e2ae15ce21644
Source noteuspto-grants-2011_08