3-(Difluoromethyl)-6-(piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine → HCID 178506042, compound

HRID 1674998Notes

Reaction equation

HRID 1674998 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=O)=[N:2]1.[F:12][CH:13]([F:29])[C:14]1[N:18]2[N:19]=[C:20]([N:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[CH:21]=[CH:22][C:17]2=[N:16][N:15]=1>>[F:29][CH:13]([F:12])[C:14]1[N:18]2[N:19]=[C:20]([N:23]3[CH2:24][CH2:25][N:26]([CH2:10][C:3]4[C:4]5[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=5)[NH:1][N:2]=4)[CH2:27][CH2:28]3)[CH:21]=[CH:22][C:17]2=[N:16][N:15]=1

Participants

3

Reactant 2

HCID 673418813-(Difluoromethyl)-6-(piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazineHCID 178520025HCID 178520025, compound

Product 1

HCID 178506042HCID 178506042, compoundYield 65%

Procedure

A mixture of indazole-3-carboxaldehyde and 3-(difluoromethyl)-6-(piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 5 to give 3-(difluoromethyl)-6-[4-(1H-indazol-3-ylmethyl)piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazine in 65% yield.

Workup

  1. customto react by General Synthetic Method 5

Sources & evidence

ORD record
ord-28e97ef7cf0c4ef1aad7103ecd7a7f57
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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