6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine → 6-[4-(Cyclopropylmethoxy)piperidin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

HRID 1675003Notes

Reaction equation

HRID 1675003 reaction equation
[CH:1]1([CH2:4][O:5][CH:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:3][CH2:2]1.N1([C:18]2[CH:19]=[CH:20][C:21]3[N:22]([C:24]([C:27]([F:30])([F:29])[F:28])=[N:25][N:26]=3)[N:23]=2)CCNCC1>>[CH:1]1([CH2:4][O:5][CH:6]2[CH2:11][CH2:10][N:9]([C:18]3[CH:19]=[CH:20][C:21]4[N:22]([C:24]([C:27]([F:28])([F:30])[F:29])=[N:25][N:26]=4)[N:23]=3)[CH2:8][CH2:7]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 14768626-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineHCID 171780104-(Cyclopropylmethoxy)piperidine

Product 1

HCID 591497316-[4-(Cyclopropylmethoxy)piperidin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineYield 69%

Procedure

A mixture of 4-(cyclopropylmethoxy)piperidine and 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 216 to give 6-[4-(cyclopropylmethoxy)piperidin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine in 69% yield.

Workup

  1. customto react by an analogous method to Example 216

Sources & evidence

ORD record
ord-6591d211eee640a89ecb775eac288405
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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