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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1675003Generated: October 30, 2026

6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine → 6-[4-(Cyclopropylmethoxy)piperidin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

https://huagongshe.com/reaction/1675003

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineHCID 1476862—
Reactant4-(Cyclopropylmethoxy)piperidineHCID 17178010—
Product6-[4-(Cyclopropylmethoxy)piperidin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineHCID 5914973169%

Reaction Steps

A mixture of 4-(cyclopropylmethoxy)piperidine and 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 216 to give 6-[4-(cyclopropylmethoxy)piperidin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine in 69% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08003649B2
Source datasetuspto-grants-2011_08
ORD IDord-6591d211eee640a89ecb775eac288405
Source noteuspto-grants-2011_08