6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine → HCID 59149815, compound

HRID 1675015Notes

Reaction equation

HRID 1675015 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1([OH:13])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.Cl[C:15]1[CH:16]=[CH:17][C:18]2[N:19]([C:21]([C:24]([F:27])([F:26])[F:25])=[N:22][N:23]=2)[N:20]=1>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1([OH:13])[CH2:8][CH2:9][N:10]([C:15]2[CH:16]=[CH:17][C:18]3[N:19]([C:21]([C:24]([F:25])([F:27])[F:26])=[N:22][N:23]=3)[N:20]=2)[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 6136576-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazineHCID 36133634-(Pyridin-2-yl)piperidin-4-ol

Product 1

HCID 59149815HCID 59149815, compoundYield 77%

Procedure

A mixture of 4-(pyridin-2-yl)piperidin-4-ol and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by the method of Example 306 to give 4-pyridin-2-yl-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol in 77% yield.

Workup

  1. customto react by the method of Example 306

Sources & evidence

ORD record
ord-7dcbc6b8f44f4f7aa125db07e303d7ea
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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