6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine → HCID 59149756, compound

HRID 1675016Notes

Reaction equation

HRID 1675016 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([C:9]2([OH:15])[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[N:7][CH:8]=1.Cl[C:19]1[CH:20]=[CH:21][C:22]2[N:23]([C:25]([C:28]([F:31])([F:30])[F:29])=[N:26][N:27]=2)[N:24]=1>>[F:17][C:2]([F:1])([F:16])[C:3]1[CH:4]=[C:5]([C:9]2([OH:15])[CH2:10][CH2:11][N:12]([C:19]3[CH:20]=[CH:21][C:22]4[N:23]([C:25]([C:28]([F:29])([F:31])[F:30])=[N:26][N:27]=4)[N:24]=3)[CH2:13][CH2:14]2)[CH:6]=[N:7][CH:8]=1

Participants

3

Reactant 2

HCID 6136576-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazineHCID 67339423HCID 67339423, compound

Product 1

HCID 59149756HCID 59149756, compoundYield 75%

Procedure

A mixture of 4-[5-(trifluoromethyl)pyridin-3-yl]piperidin-4-ol and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by the method of Example 306 to give 4-[5-(trifluoromethyl)pyridin-3-yl]-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol in 75% yield.

Workup

  1. customto react by the method of Example 306

Sources & evidence

ORD record
ord-1daea9537e944ba3abca7bed9d11b11c
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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