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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1675039Generated: October 26, 2026

6-Chloro-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine → 6-(4-Benzyl-2-methylpiperazin-1-yl)-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine

https://huagongshe.com/reaction/1675039

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Chloro-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazineHCID 1489114—
Reactant1-Benzyl-3-methylpiperazineHCID 2727520—
Product6-(4-Benzyl-2-methylpiperazin-1-yl)-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazineHCID 5914969541%

Reaction Steps

A mixture of 1-benzyl-3-methyl-piperazine and 6-chloro-3-[chloro(difluoro)methyl]-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 339 to give 6-(4-benzyl-2-methylpiperazin-1-yl)-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine in 41% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08003649B2
Source datasetuspto-grants-2011_08
ORD IDord-cd1bd3c30832461d93b6a056bed38ae8
Source noteuspto-grants-2011_08