6-Chloro-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine → 6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine

HRID 1675041Notes

Reaction equation

HRID 1675041 reaction equation
Cl.[CH2:2]([N:9]1[CH2:16][CH:15]2[CH:11]([CH2:12][NH:13][CH2:14]2)[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl[C:18]1[CH:19]=[CH:20][C:21]2[N:22]([C:24]([C:27]([Cl:30])([F:29])[F:28])=[N:25][N:26]=2)[N:23]=1>>[CH2:2]([N:9]1[CH2:10][CH:11]2[CH2:12][N:13]([C:18]3[CH:19]=[CH:20][C:21]4[N:22]([C:24]([C:27]([Cl:30])([F:29])[F:28])=[N:25][N:26]=4)[N:23]=3)[CH2:14][CH:15]2[CH2:16]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 14891146-Chloro-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazineHCID 673397792-Benzyloctahydropyrrolo[3,4-c]pyrrole hydrochloride

Product 1

HCID 591496996-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazineYield 66%

Procedure

A mixture of 2-benzylhexahydropyrrolo[3,4-c]pyrrole hydrochloride and 6-chloro-3-[chloro(difluoro)methyl]-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 331 to give 6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine in 66% yield.

Workup

  1. customto react by an analogous method to Example 331

Sources & evidence

ORD record
ord-e37d126d07a242088de91eb5ff5c34fd
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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