HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine → 6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine | HCID 1489114 | — |
| Reactant | 2-Benzyloctahydropyrrolo[3,4-c]pyrrole hydrochloride | HCID 67339779 | — |
| Product | 6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine | HCID 59149699 | 66% |
Reaction Steps
A mixture of 2-benzylhexahydropyrrolo[3,4-c]pyrrole hydrochloride and 6-chloro-3-[chloro(difluoro)methyl]-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 331 to give 6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine in 66% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003649B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-e37d126d07a242088de91eb5ff5c34fd |
| Source note | uspto-grants-2011_08 |