6-Chloro-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine → HCID 59149725, compound

HRID 1675042Notes

Reaction equation

HRID 1675042 reaction equation
Cl.[C:2]1([CH:8]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([C:25]([Cl:28])([F:27])[F:26])=[N:23][N:24]=2)[N:21]=1>>[Cl:28][C:25]([F:26])([F:27])[C:22]1[N:20]2[N:21]=[C:16]([N:11]3[CH2:12][CH2:13][CH2:14][CH:8]([C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[CH2:9][CH2:10]3)[CH:17]=[CH:18][C:19]2=[N:24][N:23]=1

Participants

3

Reactant 2

HCID 14891146-Chloro-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazineHCID 2420066373252-01-4

Product 1

HCID 59149725HCID 59149725, compoundYield 69%

Procedure

A mixture of 4-phenylazepane hydrochloride and 6-chloro-3-[chloro(difluoro)methyl]-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 331 to give 3-[chloro(difluoro)methyl]-6-(4-phenylazepan-1-yl)[1,2,4]triazolo[4,3-b]pyridazine in 69% yield.

Workup

  1. customto react by an analogous method to Example 331

Sources & evidence

ORD record
ord-fe1e3deb2e0c4ffc871ee0b7f86f169f
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

Loading…