1-Thiophen-2-ylmethyl-piperazine → HCID 59149705, compound

HRID 1675043Notes

Reaction equation

HRID 1675043 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.Cl[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([C:23]([Cl:26])([F:25])[F:24])=[N:21][N:22]=2)[N:19]=1>>[Cl:26][C:23]([F:24])([F:25])[C:20]1[N:18]2[N:19]=[C:14]([N:10]3[CH2:9][CH2:8][N:7]([CH2:6][C:2]4[S:1][CH:5]=[CH:4][CH:3]=4)[CH2:12][CH2:11]3)[CH:15]=[CH:16][C:17]2=[N:22][N:21]=1

Participants

3

Reactant 2

HCID 5662081-Thiophen-2-ylmethyl-piperazineHCID 14891146-Chloro-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine

Product 1

HCID 59149705HCID 59149705, compoundYield 74%

Procedure

A mixture of 1-(thiophen-2-ylmethyl)piperazine and 6-chloro-3-[chloro(difluoro)methyl]-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 339 to give 3-[chloro(difluoro)methyl]-6-[4-(thiophen-2-ylmethyl)piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazine in 74% yield.

Workup

  1. customto react by an analogous method to Example 339

Sources & evidence

ORD record
ord-c3eee48ccdd04b4da05cd23b686d891e
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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