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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1675044Generated: October 25, 2026

6-Chloro-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine → 3-[Chloro(difluoro)methyl]-6-[4-(thiophen-3-ylmethyl)piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazine

https://huagongshe.com/reaction/1675044

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Chloro-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazineHCID 1489114—
Reactant1-(Thiophen-3-ylmethyl)piperazineHCID 3494696—
Product3-[Chloro(difluoro)methyl]-6-[4-(thiophen-3-ylmethyl)piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazineHCID 5914968970%

Reaction Steps

A mixture of 1-(thiophen-3-ylmethyl)piperazine and 6-chloro-3-[chloro(difluoro)methyl]-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 339 to give 3-[chloro(difluoro)methyl]-6-[4-(thiophen-3-ylmethyl)piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazine in 70% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08003649B2
Source datasetuspto-grants-2011_08
ORD IDord-a4e75312db6e40a6974ff4abe7a3fbc0
Source noteuspto-grants-2011_08