4-Pyridinecarboxaldehyde → HCID 59149811, compound

HRID 1675045Notes

Reaction equation

HRID 1675045 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=O)=[CH:3][CH:2]=1.[CH3:9][C@H:10]1[CH2:15][NH:14][CH2:13][CH2:12][N:11]1[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([C:25]([F:28])([F:27])[F:26])=[N:23][N:24]=2)[N:21]=1>>[CH3:9][C@H:10]1[CH2:15][N:14]([CH2:7][C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[CH2:13][CH2:12][N:11]1[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([C:25]([F:27])([F:26])[F:28])=[N:23][N:24]=2)[N:21]=1

Participants

3

Reactant 2

HCID 133894-PyridinecarboxaldehydeHCID 67341149HCID 67341149, compound

Product 1

HCID 59149811HCID 59149811, compoundYield 53%

Procedure

A mixture of pyridine-4-carboxaldehyde and 6-[(2S)-2-methylpiperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 5 to give 6-[(2S)-2-methyl-4-(pyridin-4-ylmethyl)piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine in 53% yield.

Workup

  1. customto react by General Synthetic Method 5

Sources & evidence

ORD record
ord-cf346ca0bd8446f5836af6f026275164
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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