6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine → HCID 59149789, compound

HRID 1675046Notes

Reaction equation

HRID 1675046 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([CH:8]=O)[CH:5]=[CH:4][CH:3]=1.[N:10]1([C:16]2[CH:17]=[CH:18][C:19]3[N:20]([C:22]([C:25]([F:28])([F:27])[F:26])=[N:23][N:24]=3)[N:21]=2)[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>>[Br:1][C:2]1[N:7]=[C:6]([CH2:8][N:13]2[CH2:12][CH2:11][N:10]([C:16]3[CH:17]=[CH:18][C:19]4[N:20]([C:22]([C:25]([F:26])([F:27])[F:28])=[N:23][N:24]=4)[N:21]=3)[CH2:15][CH2:14]2)[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14768626-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineHCID 27570096-Bromopyridine-2-carbaldehyde

Product 1

HCID 59149789HCID 59149789, compoundYield 66%

Procedure

A mixture of 6-bromopyridine-2-carboxaldehyde and 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 5 to give 6-[4-[(6-bromopyridin-2-yl)methyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine in 66% yield.

Workup

  1. customto react by General Synthetic Method 5

Sources & evidence

ORD record
ord-9aa6f3ed2d6a48f8a69a33500d6c08b3
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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