6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine → 6-[3-(Phenoxymethyl)piperidin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

HRID 1675110Notes

Reaction equation

HRID 1675110 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]([F:14])([F:13])[F:12])=[N:9][N:10]=2)[N:7]=1.[O:15]([CH2:22][CH:23]1[CH2:28][CH2:27][CH2:26][NH:25][CH2:24]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[O:15]([CH2:22][CH:23]1[CH2:28][CH2:27][CH2:26][N:25]([C:2]2[CH:3]=[CH:4][C:5]3[N:6]([C:8]([C:11]([F:14])([F:13])[F:12])=[N:9][N:10]=3)[N:7]=2)[CH2:24]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 6136576-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazineHCID 156700933-(Phenoxymethyl)piperidine

Product 1

HCID 591497996-[3-(Phenoxymethyl)piperidin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineYield 60%

Procedure

Obtained in 60% yield by an analogous method to Example 515, starting from 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine and 3-(phenoxymethyl)piperidine.

Workup

  1. customObtained in 60% yield by an analogous method to Example 515

Sources & evidence

ORD record
ord-764cb81a4be84e589017a7a71e906db4
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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