3-Pyridinecarboxaldehyde → HCID 59149720, compound

HRID 1675111Notes

Reaction equation

HRID 1675111 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=O)[CH:2]=1.[C@@H:9]12[NH:16][C@@H:13]([CH2:14][CH2:15]1)[CH2:12][N:11]([C:17]1[CH:18]=[CH:19][C:20]3[N:21]([C:23]([C:26]([F:29])([F:28])[F:27])=[N:24][N:25]=3)[N:22]=1)[CH2:10]2>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][N:16]2[C@H:9]3[CH2:15][CH2:14][C@@H:13]2[CH2:12][N:11]([C:17]2[CH:18]=[CH:19][C:20]4[N:21]([C:23]([C:26]([F:29])([F:27])[F:28])=[N:24][N:25]=4)[N:22]=2)[CH2:10]3)[CH:2]=1

Participants

3

Reactant 2

HCID 103713-PyridinecarboxaldehydeHCID 67340155HCID 67340155, compound

Product 1

HCID 59149720HCID 59149720, compoundYield 68%

Procedure

A mixture of pyridine-3-carboxaldehyde and 6-[(1R,5S)-3,8-diazabicyclo[3.2.1]oct-3-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 5 to give 6-[(1R,5S)-8-(pyridin-3-ylmethyl)-3,8-diazabicyclo[3.2.1]oct-3-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine in 68% yield.

Workup

  1. customto react by General Synthetic Method 5

Sources & evidence

ORD record
ord-f1aa38be76264a8e834cbac9d809cd14
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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