3-Pyridinecarboxaldehyde → HCID 59149773, compound

HRID 1675118Notes

Reaction equation

HRID 1675118 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=O)[CH:2]=1.[CH3:9][C@@H:10]1[NH:15][CH2:14][CH2:13][N:12]([C:16]2[CH:17]=[CH:18][C:19]3[N:20]([C:22]([C:25]([F:28])([F:27])[F:26])=[N:23][N:24]=3)[N:21]=2)[CH2:11]1>>[CH3:9][C@@H:10]1[N:15]([CH2:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[CH2:14][CH2:13][N:12]([C:16]2[CH:17]=[CH:18][C:19]3[N:20]([C:22]([C:25]([F:27])([F:26])[F:28])=[N:23][N:24]=3)[N:21]=2)[CH2:11]1

Participants

3

Reactant 2

HCID 103713-PyridinecarboxaldehydeHCID 67340626HCID 67340626, compound

Product 1

HCID 59149773HCID 59149773, compoundYield 62%

Procedure

A mixture of pyridine-3-carboxaldehyde and 6-[(3S)-3-methylpiperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 5 to give 6-[(3S)-3-methyl-4-(pyridin-3-ylmethyl)piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine in 62% yield.

Workup

  1. customto react by General Synthetic Method 5

Sources & evidence

ORD record
ord-b8c5ec3209b244c19e7e3826a47b8672
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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