6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine → HCID 59149812, compound

HRID 1675120Notes

Reaction equation

HRID 1675120 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[N:7]2[N:8]=[C:9]([N:12]3[CH2:16][CH2:15][C@@H:14]([OH:17])[CH2:13]3)[CH:10]=[CH:11][C:6]2=[N:5][N:4]=1.ClC1[CH:22]=[CH:23][C:24]2[N:25]([C:27]([C:30](F)(F)F)=NN=2)N=1.N1CC[C@@H](O)C1>>[N:25]1[CH:24]=[CH:23][CH:22]=[C:30]([O:17][C@H:14]2[CH2:15][CH2:16][N:12]([C:9]3[CH:10]=[CH:11][C:6]4[N:7]([C:3]([C:2]([F:1])([F:18])[F:19])=[N:4][N:5]=4)[N:8]=3)[CH2:13]2)[CH:27]=1

Participants

4

Reactant 3

HCID 6136576-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazineHCID 2759337(R)-3-PyrrolidinolHCID 67340586HCID 67340586, compound

Product 1

HCID 59149812HCID 59149812, compound

Procedure

The (3R)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]pyrrolidin-3-ol used as starting material was prepared in 81% yield by an analogous method to Example 216, preparation of starting materials, starting from 6-chloro-3-(trifluoromethyl)-[1,2,4]-triazolo[4,3-b]pyridazine and (R)-pyrrolidin-3-ol.

Workup

  1. customwas prepared in 81% yield by an analogous method to Example 216, preparation of starting materials

Sources & evidence

ORD record
ord-17039e9ffc4e4b03bd23f037b7706e0b
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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