6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine → 6-[4-[(2-Methylpyridin-4-yl)methyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

HRID 1675139Notes

Reaction equation

HRID 1675139 reaction equation
[N:1]1([C:7]2[CH:8]=[CH:9][C:10]3[N:11]([C:13]([C:16]([F:19])([F:18])[F:17])=[N:14][N:15]=3)[N:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH3:20][C:21]1[CH:26]=[C:25]([CH:27]=O)[CH:24]=[CH:23][N:22]=1>>[CH3:20][C:21]1[CH:26]=[C:25]([CH2:27][N:4]2[CH2:3][CH2:2][N:1]([C:7]3[CH:8]=[CH:9][C:10]4[N:11]([C:13]([C:16]([F:17])([F:18])[F:19])=[N:14][N:15]=4)[N:12]=3)[CH2:6][CH2:5]2)[CH:24]=[CH:23][N:22]=1

Participants

3

Reactant 2

HCID 14768626-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineHCID 27630002-METHYLISONICOTINALDEHYDE

Product 1

HCID 591497196-[4-[(2-Methylpyridin-4-yl)methyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineYield 61%

Procedure

Obtained in 61% yield by General Synthetic Method 5, starting from 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine and 2-methylpyridine-4-carboxaldehyde

Workup

  1. customObtained in 61% yield by General Synthetic Method 5

Sources & evidence

ORD record
ord-6a37bddc208642708665e589274c553d
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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