Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1675139Generated: November 2, 2026

6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine → 6-[4-[(2-Methylpyridin-4-yl)methyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

https://huagongshe.com/reaction/1675139

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineHCID 1476862—
Reactant2-METHYLISONICOTINALDEHYDEHCID 2763000—
Product6-[4-[(2-Methylpyridin-4-yl)methyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineHCID 5914971961%

Reaction Steps

Obtained in 61% yield by General Synthetic Method 5, starting from 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine and 2-methylpyridine-4-carboxaldehyde

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08003649B2
Source datasetuspto-grants-2011_08
ORD IDord-6a37bddc208642708665e589274c553d
Source noteuspto-grants-2011_08