4-Pyridinecarboxaldehyde → HCID 59149712, compound

HRID 1675148Notes

Reaction equation

HRID 1675148 reaction equation
[CH3:1][C@H:2]1[NH:7][CH2:6][CH2:5][N:4]([C:8]2[CH:9]=[CH:10][C:11]3[N:12]([C:14]([C:17]([F:20])([F:19])[F:18])=[N:15][N:16]=3)[N:13]=2)[CH2:3]1.[N:21]1[CH:26]=[CH:25][C:24]([CH:27]=O)=[CH:23][CH:22]=1>>[CH3:1][C@H:2]1[N:7]([CH2:27][C:24]2[CH:25]=[CH:26][N:21]=[CH:22][CH:23]=2)[CH2:6][CH2:5][N:4]([C:8]2[CH:9]=[CH:10][C:11]3[N:12]([C:14]([C:17]([F:18])([F:20])[F:19])=[N:15][N:16]=3)[N:13]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 133894-PyridinecarboxaldehydeHCID 67340938HCID 67340938, compound

Product 1

HCID 59149712HCID 59149712, compoundYield 58%

Procedure

Obtained in 58% yield by General Synthetic Method 5, starting from 6-[(3R)-3-methylpiperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine (obtained as described in Example 564, preparation of starting materials) and pyridine-4-carboxaldehyde.

Workup

  1. customObtained in 58% yield by General Synthetic Method 5

Sources & evidence

ORD record
ord-a652d398efc04dd8933c63626e42e5a0
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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