4-(1-(3-(Trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenol → HCID 59149697, compound

HRID 1675153Notes

Reaction equation

HRID 1675153 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[CH2:16][CH2:15][N:14]([C:17]3[CH:18]=[CH:19][C:20]4[N:21]([C:23]([C:26]([F:29])([F:28])[F:27])=[N:24][N:25]=4)[N:22]=3)[CH2:13][CH2:12]2)=[CH:7][CH:6]=1.FC(F)(F)C1[N:36]2[N:37]=[C:38](N3CCC(C4C=CC(O)=CC=4)CC3)[CH:39]=[CH:40]C2=NN=1>>[N:37]1([CH2:2][CH2:3][O:4][C:5]2[CH:10]=[CH:9][C:8]([CH:11]3[CH2:16][CH2:15][N:14]([C:17]4[CH:18]=[CH:19][C:20]5[N:21]([C:23]([C:26]([F:29])([F:28])[F:27])=[N:24][N:25]=5)[N:22]=4)[CH2:13][CH2:12]3)=[CH:7][CH:6]=2)[CH:38]=[CH:39][CH:40]=[N:36]1

Participants

3

Reactant 2

HCID 367300784-(1-(3-(Trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenolHCID 66788323HCID 66788323, compound

Product 1

HCID 59149697HCID 59149697, compound

Procedure

The starting 6-[4-[4-(2-bromoethoxy)phenyl]piperidin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was obtained in 29% yield by an analogous method to Example 847, preparation of starting materials, starting from 4-[4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-1-yl]phenol (obtained as described in Example 513, preparation of starting materials).

Sources & evidence

ORD record
ord-8ef1e63edd3a43a2b8205f35b7dcb445
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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