HCID 67340921, compound → HCID 59149783, compound

HRID 1675159Notes

Reaction equation

HRID 1675159 reaction equation
[F:1][CH:2]([F:25])[C:3]1[N:7]2[N:8]=[C:9]([N:12]3[CH2:17][CH2:16][N:15]([C:18]4[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=4)[CH2:14][CH2:13]3)[CH:10]=[CH:11][C:6]2=[N:5][N:4]=1.C(N1CCN([C:45]2[CH:46]=C[C:48]3[N:49]([C:51]([C:54](F)(F)[CH:55](F)F)=NN=3)[N:50]=2)CC1)(C1C=CC=CC=1)C1C=CC=CC=1>>[F:25][CH:2]([F:1])[C:3]1[N:7]2[N:8]=[C:9]([N:12]3[CH2:17][CH2:16][N:15]([C:18]4[CH:23]=[CH:22][C:21]([O:24][CH2:55][CH2:54][C:51]5[N:49]([CH3:48])[N:50]=[CH:45][CH:46]=5)=[CH:20][CH:19]=4)[CH2:14][CH2:13]3)[CH:10]=[CH:11][C:6]2=[N:5][N:4]=1

Participants

3

Reactant 2

HCID 67340921HCID 67340921, compoundHCID 866380846-[4-(Diphenylmethyl)-1-piperazinyl]-3-(1,1,2,2-tetrafluoroethyl)-1,2,4-triazolo[4,3-b]pyridazine

Product 1

HCID 59149783HCID 59149783, compound

Procedure

The 4-[4-[3-(difluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl]phenol used as starting material was prepared in 95% yield by an analogous method to Example 514, preparation of starting materials, starting from 3-(difluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine (obtained as described in General Synthetic Method 1, preparation of starting materials).

Workup

  1. customwas prepared in 95% yield by an analogous method to Example 514, preparation of starting materials

Sources & evidence

ORD record
ord-7358b849928c45f991ec237324d4c406
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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