2-(Dimethylamino)ethanol → 4-[4-[2-(Dimethylamino)ethoxy]phenyl]-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

HRID 1675165Notes

Reaction equation

HRID 1675165 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:27])[CH2:13][CH2:12][N:11]([C:14]3[CH:15]=[CH:16][C:17]4[N:18]([C:20]([C:23]([F:26])([F:25])[F:24])=[N:21][N:22]=4)[N:19]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:28][N:29]([CH3:33])[CH2:30][CH2:31]O>>[CH3:28][N:29]([CH3:33])[CH2:30][CH2:31][O:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:27])[CH2:13][CH2:12][N:11]([C:14]3[CH:15]=[CH:16][C:17]4[N:18]([C:20]([C:23]([F:26])([F:25])[F:24])=[N:21][N:22]=4)[N:19]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 79022-(Dimethylamino)ethanolHCID 667887034-(4-Hydroxyphenyl)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

Product 1

HCID 591498004-[4-[2-(Dimethylamino)ethoxy]phenyl]-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-olYield 74%

Procedure

Obtained in 74% yield by an analogous method to Example 860, starting from 4-(4-hydroxyphenyl)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol and 2-(dimethylamino)ethanol.

Workup

  1. customObtained in 74% yield by an analogous method to Example 860

Sources & evidence

ORD record
ord-81b2583e066b490daabd0ee50506659d
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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