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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1675165Generated: November 1, 2026

2-(Dimethylamino)ethanol → 4-[4-[2-(Dimethylamino)ethoxy]phenyl]-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

https://huagongshe.com/reaction/1675165

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Dimethylamino)ethanolHCID 7902—
Reactant4-(4-Hydroxyphenyl)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-olHCID 66788703—
Product4-[4-[2-(Dimethylamino)ethoxy]phenyl]-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-olHCID 5914980074%

Reaction Steps

Obtained in 74% yield by an analogous method to Example 860, starting from 4-(4-hydroxyphenyl)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol and 2-(dimethylamino)ethanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08003649B2
Source datasetuspto-grants-2011_08
ORD IDord-81b2583e066b490daabd0ee50506659d
Source noteuspto-grants-2011_08