Hydrochloric Acid → HCID 22276312, compound

HRID 1675188Notes

Reaction equation

HRID 1675188 reaction equation
[Cl:1]C1C=C(N)C=C(Cl)C=1OC1C=[N:11]C2C(C=1)=CC=CC=2.Cl[C:22]1[CH:27]=[C:26](Cl)[CH:25]=[CH:24][C:23]=1[S:29](Cl)(=[O:31])=[O:30].Cl>>[ClH:1].[C:23]1([S:29]([NH2:11])(=[O:31])=[O:30])[CH:24]=[CH:25][CH:26]=[CH:27][CH:22]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 204419Benzenesulfonyl chloride, 2,4-dichloro-HCID 21129881HCID 21129881, compound

Product 1

HCID 22276312HCID 22276312, compoundYield 99%

Procedure

3,5-dichloro-4-(quinolin-3-yloxy)-phenylamine (5) was then reacted with 2,4-dichlorobenzenesulfonylchloride, followed by treatment with hydrochloric acid, to give 2,4-dichloro-N-[3,5-dichloro-4-quinolin-3-yloxy)phenyl]-benzenesulfonamide HCl (1; the hydrochloride salt of compound 101) in 99% yield.

Sources & evidence

ORD record
ord-f5f695bf247a4480a5401a02f4cc43e4
Source dataset
uspto-grants-2011_08
Patent number
US08003665B2

Reaction notes

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