反应详情

To an ethanol solution (50 mL) of tert-butyl 1-(1-amino-1-cyanoethyl)-1-cyclopropanecarboxylate (1.12 g, 5.30 mmol) was added an ethanol suspension (30 mL) of Raney Nickel catalyst (R-100 manufactured by NIKKO RICA CORPORATION, 10 mL), and the mixture was stirred vigorously under hydrogen atmosphere at room temperature for 6 hours. The catalyst was removed by filtration through celite, and the solvent was removed under reduced pressure to obtain 0.84 g of a crude product of the target compound (3.92 mmol, 74%) as transparent and colorless oil. The obtained crude product was used for the subsequent reaction without further purification.

1. customThe catalyst was removed by filtration through celite
2. customthe solvent was removed under reduced pressure