tert-Butyl 1-(1-amino-1-cyanoethyl)-1-cyclopropanecarboxylate → Tert-butyl 1-(1,2-diamino-1-methylethyl)-1-cyclopropanecarboxylate

Participants

Reaction Steps

To an ethanol solution (50 mL) of tert-butyl 1-(1-amino-1-cyanoethyl)-1-cyclopropanecarboxylate (1.12 g, 5.30 mmol) was added an ethanol suspension (30 mL) of Raney Nickel catalyst (R-100 manufactured by NIKKO RICA CORPORATION, 10 mL), and the mixture was stirred vigorously under hydrogen atmosphere at room temperature for 6 hours. The catalyst was removed by filtration through celite, and the solvent was removed under reduced pressure to obtain 0.84 g of a crude product of the target compound (3.92 mmol, 74%) as transparent and colorless oil. The obtained crude product was used for the subsequent reaction without further purification.

Provenance & Evidence