Hydrochloric Acid → 1-(1,2-Diamino-1-methylethyl)-1-cyclopropanecarboxylate dihydrochloride
Reaction equation
[NH2:1][C:2]([C:6]1([C:9]([O:11]C(C)(C)C)=[O:10])[CH2:8][CH2:7]1)([CH3:5])[CH2:3][NH2:4].O.[ClH:17]>>[ClH:17].[ClH:17].[NH2:1][C:2]([C:6]1([C:9]([OH:11])=[O:10])[CH2:7][CH2:8]1)([CH3:5])[CH2:3][NH2:4]Participants
4
Procedure
At room temperature, 0.82 g (3.83 mmol) of the crude product of tert-butyl 1-(1,2-diamino-1-methylethyl)-1-cyclopropanecarboxylate was dissolved in concentrated hydrochloric acid (5 mL), and the mixture was stirred at the same temperature for 30 minutes. To the reaction solution was added water, subsequently the solvent was removed under reduced pressure. And then the solution was subjected to azeotropy with ethanol (twice). As a result, 0.82 g of a crude product of the target compound (3.55 mmol, 930) was obtained as a light yellow foam-like solid. The obtained crude product was used for the subsequent reaction without further purification.
Workup
- customsubsequently the solvent was removed under reduced pressure
- customAs a result, 0.82 g of a crude product of the target compound (3.55 mmol, 930) was obtained as a light yellow foam-like solid
- customThe obtained crude product
- customwas used for the subsequent reaction without further purification
Sources & evidence
- ORD record
- ord-6071a0df15e84a4f81b6474bf7634ce0
- Source dataset
- uspto-grants-2011_08
- Patent number
- US08003666B2
Reaction notes
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