1-Methylpiperazine → HCID 11606584, compound

HRID 1675210Notes

Reaction equation

Cl[CH2:2][C:3]([NH:5][CH2:6][CH2:7][C:8]([NH:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][CH:20]=1)[N:17]=[CH:16][N:15]=[C:14]2[NH:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][C:29]2[CH:30]=[N:31][C:32]([CH3:35])=[CH:33][CH:34]=2)=[C:24]([CH3:36])[CH:23]=1)=[O:9])=[O:4].[CH3:37][N:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1>>[CH3:36][C:24]1[CH:23]=[C:22]([NH:21][C:14]2[C:13]3[C:18](=[CH:19][CH:20]=[C:11]([NH:10][C:8](=[O:9])[CH2:7][CH2:6][NH:5][C:3](=[O:4])[CH2:2][N:41]4[CH2:42][CH2:43][N:38]([CH3:37])[CH2:39][CH2:40]4)[CH:12]=3)[N:17]=[CH:16][N:15]=2)[CH:27]=[CH:26][C:25]=1[O:28][C:29]1[CH:30]=[N:31][C:32]([CH3:35])=[CH:33][CH:34]=1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 11555204HCID 11555204, compound

Product 1

HCID 11606584HCID 11606584, compoundYield 51%

Procedure

The procedure of Example 62 was repeated except for using 0.07 g of the compound obtained in Example 67 and 0.05 ml of 1-methylpiperazine instead of the compound obtained in Example 61 to obtain the title compound (0.04 g, 51%).

Sources & evidence

ORD record: ord-a3478c121d094c2fbd692122d1ce39b3
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08003658B2

Reaction notes

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