Pyridine → 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

Participants

Reaction Steps

36 μl of pyridine, 100 mg of the compound obtained in (87-1) of Example 87 and 80 mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride were added to 30 μl of acrylic acid dissolved in 2 ml of THF, and reacted at 0° C. for 5 hours. The reacted solution was washed with saturated sodium bicarbonate, dried over sodium sulfate, filtered and distilled under a reduced pressure, and the resulting residue was subjected to column chromatography (eluent-chloroform:methanol=15:1) to obtain the title compound (14 mg, 13%).

Provenance & Evidence