Pyridine → 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride
Reaction equation
NCCCC(NC1C=[C:10]2[C:15](=[CH:16][CH:17]=1)[N:14]=[CH:13][N:12]=[C:11]2NC1C=CC(OCC2C=CC=C(F)C=2)=C([Cl:34])C=1)=O.[N:35]1[CH:40]=CC=C[CH:36]=1>>[ClH:34].[CH3:36][N:35]([CH3:40])[CH2:17][CH2:16][CH2:15][N:14]=[C:13]=[N:12][CH2:11][CH3:10]Participants
3
Procedure
36 μl of pyridine, 100 mg of the compound obtained in (87-1) of Example 87 and 80 mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride were added to 30 μl of acrylic acid dissolved in 2 ml of THF, and reacted at 0° C. for 5 hours. The reacted solution was washed with saturated sodium bicarbonate, dried over sodium sulfate, filtered and distilled under a reduced pressure, and the resulting residue was subjected to column chromatography (eluent-chloroform:methanol=15:1) to obtain the title compound (14 mg, 13%).
Sources & evidence
- ORD record
- ord-e869b1e4e8fe48f79d88d7cc17da5f7a
- Source dataset
- uspto-grants-2011_08
- Patent number
- US08003658B2
Reaction notes
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