Methylamine → HCID 67333074, compound

HRID 1675228Notes

Reaction equation

HRID 1675228 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:17][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([NH:28][C:29](=[O:35])[CH2:30][CH2:31][N:32](C)[CH3:33])[CH:26]=3)[N:21]=[CH:20][N:19]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=1.CN>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:17][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([NH:28][C:29](=[O:35])[CH2:30][CH2:31][NH:32][CH3:33])[CH:26]=3)[N:21]=[CH:20][N:19]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 67334443HCID 67334443, compound

Product 1

HCID 67333074HCID 67333074, compoundYield 96%

Procedure

The procedure of (141-2) of Example 141 was repeated except for using methylamine instead of dimethylamine to obtain the title compound (0.41 g, 96%).

Sources & evidence

ORD record
ord-eb41f0e91cce4213aa89712096587afe
Source dataset
uspto-grants-2011_08
Patent number
US08003658B2

Reaction notes

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