Trifluoroacetic acid → HCID 57835804, compound

HRID 1675287Notes

Reaction equation

HRID 1675287 reaction equation
C(O)(C(F)(F)F)=O.COC1C=CC(C[O:15][C:16]2[CH:21]=[CH:20][C:19]([CH:22]([C:36]3[CH2:40][CH2:39][O:38][N:37]=3)[CH2:23][C:24]([O:26]CC3C=CC(OC)=CC=3)=[O:25])=[CH:18][CH:17]=2)=CC=1>C(Cl)Cl>[O:38]1[CH2:39][CH2:40][C:36]([CH:22]([C:19]2[CH:18]=[CH:17][C:16]([OH:15])=[CH:21][CH:20]=2)[CH2:23][C:24]([OH:26])=[O:25])=[N:37]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57835744HCID 57835744, compound

Product 1

HCID 57835804HCID 57835804, compoundYield 101.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (1 mL) was added to 42.1 (100 mg) in DCM (1 mL). The mixture was stirred at room temperature for 40 hours. TFA and DCM were removed under vacuum, and the residue was treated with EtOH (50 mL). The insoluble solid was removed by filtration. The filtrate was concentrated to give 42.2 (50 mg), which was used in the next step without further purification. MS ESI (pos.) m/e: 236 (M+H).

Workup

  1. customTFA and DCM were removed under vacuum
  2. additionthe residue was treated with EtOH (50 mL)
  3. customThe insoluble solid was removed by filtration
  4. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-bbe1594e2b964b9fa2a96dc8dcd02ee9
Source dataset
uspto-grants-2011_08
Patent number
US08003648B2

Reaction notes

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