反应详情

Under nitrogen, add 0.18 g of 2-chloro-1-methylpyridinium iodide, 0.25 ml of triethylamine and 0.04 ml of ethylamine in dichloromethane to a solution of 0.20 g of the compound obtained in Step C of Example 1 in 20 ml of dichloromethane and then heat at reflux for 14 hours. Dilute the reaction mixture with dichloromethane and wash with saturated aqueous sodium chloride solution. Extract and dry the organic phase over sodium sulfate and then filter and evaporate. Purify the compound by column chromatography on silica gel using as eluant a 19/1 dichloromethane/ethanol mixture. After triturating in diisopropyl ether, the title compound is obtained in the form of a white solid.

1. temperatureheat
2. temperatureat reflux for 14 hours
3. washwash with saturated aqueous sodium chloride solution
4. extractionExtract
5. dry with materialdry the organic phase over sodium sulfate
6. filtrationfilter
7. customevaporate
8. customPurify the compound by column chromatography on silica gel using as eluant a 19/1 dichloromethane/ethanol mixture
9. customAfter triturating in diisopropyl ether