2-Cyclopropylethanamine hydrochloride → N-(2-Cyclopropylethyl)-6-[5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo-[3,4-c]pyrrol-2-yl]nicotinamide

HRID 1675358Notes

Reaction equation

HRID 1675358 reaction equation
[F:1][C:2]([F:29])([F:28])[C:3]1[CH:27]=[CH:26][CH:25]=[CH:24][C:4]=1[C:5]([N:7]1[CH2:11][C:10]2[CH2:12][N:13]([C:15]3[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][N:16]=3)[CH2:14][C:9]=2[CH2:8]1)=[O:6].Cl.[CH:31]1([CH2:34][CH2:35][NH2:36])[CH2:33][CH2:32]1>>[CH:31]1([CH2:34][CH2:35][NH:36][C:19](=[O:20])[C:18]2[CH:22]=[CH:23][C:15]([N:13]3[CH2:12][C:10]4[CH2:11][N:7]([C:5](=[O:6])[C:4]5[CH:24]=[CH:25][CH:26]=[CH:27][C:3]=5[C:2]([F:29])([F:28])[F:1])[CH2:8][C:9]=4[CH2:14]3)=[N:16][CH:17]=2)[CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 219160802-Cyclopropylethanamine hydrochlorideHCID 584597846-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]nicotinic acid

Product 1

HCID 25105830N-(2-Cyclopropylethyl)-6-[5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo-[3,4-c]pyrrol-2-yl]nicotinamideYield 37%

Procedure

6-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]nicotinic acid (50 mg, 0.124 mmol) was reacted with 2-cyclopropylethylamine hydrochloride analogously to 3d. Yield: 37%, M+H+: 471.28.

Sources & evidence

ORD record
ord-b5f291b351f44a7da81c18490efde93f
Source dataset
uspto-grants-2011_08
Patent number
US08003677B2

Reaction notes

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