HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Cyclopropylethanamine hydrochloride → N-(2-Cyclopropylethyl)-6-[5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo-[3,4-c]pyrrol-2-yl]nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Cyclopropylethanamine hydrochloride | HCID 21916080 | — |
| Reactant | 6-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]nicotinic acid | HCID 58459784 | — |
| Product | N-(2-Cyclopropylethyl)-6-[5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo-[3,4-c]pyrrol-2-yl]nicotinamide | HCID 25105830 | 37% |
Reaction Steps
6-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]nicotinic acid (50 mg, 0.124 mmol) was reacted with 2-cyclopropylethylamine hydrochloride analogously to 3d. Yield: 37%, M+H+: 471.28.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003677B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-b5f291b351f44a7da81c18490efde93f |
| Source note | uspto-grants-2011_08 |