1-(1,3-Thiazol-5-yl)methanamine--hydrogen chloride (1/1) → HCID 25105853, compound

HRID 1675364Notes

Reaction equation

HRID 1675364 reaction equation
[F:1][C:2]([F:29])([F:28])[C:3]1[CH:27]=[CH:26][CH:25]=[CH:24][C:4]=1[C:5]([N:7]1[CH2:11][C:10]2[CH2:12][N:13]([C:15]3[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][N:16]=3)[CH2:14][C:9]=2[CH2:8]1)=[O:6].Cl.[S:31]1[C:35]([CH2:36][NH2:37])=[CH:34][N:33]=[CH:32]1>>[S:31]1[C:35]([CH2:36][NH:37][C:19](=[O:20])[C:18]2[CH:22]=[CH:23][C:15]([N:13]3[CH2:12][C:10]4[CH2:11][N:7]([C:5](=[O:6])[C:4]5[CH:24]=[CH:25][CH:26]=[CH:27][C:3]=5[C:2]([F:28])([F:1])[F:29])[CH2:8][C:9]=4[CH2:14]3)=[N:16][CH:17]=2)=[CH:34][N:33]=[CH:32]1

Participants

3

Reactant 2

HCID 177509681-(1,3-Thiazol-5-yl)methanamine--hydrogen chloride (1/1)HCID 584597846-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]nicotinic acid

Product 1

HCID 25105853HCID 25105853, compoundYield 58%

Procedure

6-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]nicotinic acid (50 mg, 0.124 mmol) were reacted with C-thiazol-5-ylmethylamine, hydrochloride analogously to example 3d. Yield: 58%, M+H+: 500.20.

Sources & evidence

ORD record
ord-fa3e8d7c328d46cb86dbbab903593042
Source dataset
uspto-grants-2011_08
Patent number
US08003677B2

Reaction notes

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