Hydrochloric Acid → Salcaprozate sodium

HRID 1675524Notes

Reaction equation

HRID 1675524 reaction equation
[Na].[CH:2]1[CH:3]=[CH:4][C:5]([OH:21])=[C:6]([C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O-:20])=[O:19])=[O:9])[CH:7]=1.[Na+:22].Cl>O>[CH:2]1[CH:3]=[CH:4][C:5]([OH:21])=[C:6]([C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O-:20])=[O:19])=[O:9])[CH:7]=1.[Na+:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86585230HCID 86585230, compound

Product 1

HCID 23669833Salcaprozate sodium

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Free acid of SNAC (i.e. N-(8-[2-hydroxybenzoyl]amino)caprylic acid) was prepared as follows. The monosodium SNAC prepared in Example 12 was acidified with 1 equivalent of concentrated hydrochloric acid in water and stirred. The solution was then vacuum filtered and vacuum dried to yield the free acid.

Workup

  1. filtrationvacuum filtered
  2. customvacuum dried
  3. customto yield the free acid

Sources & evidence

ORD record
ord-b7e6252b6cf04a17b2757daf0b300f11
Source dataset
uspto-grants-2011_08
Patent number
US08003697B2

Reaction notes

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