HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3,5-Dimethoxy-4-(2-propynyloxy)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3,5-Dimethoxy-4-[(prop-2-yn-1-yl)oxy]benzoic acid | HCID 13121481 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3,5-Dimethoxy-4-(2-propynyloxy)benzoyl chloride | HCID 57445669 | 85.6% |
Reaction Steps
To 100 ml of toluene were added 13.0 g of 4-(2-propynyloxy)-3,5-dimethoxybenzoic acid, 9.5 g of thionyl chloride and 50 mg of DMF, and the resulting mixture was heated under reflux for 3 hours. Thereafter, the reaction mixture which had been allowed to cool to near room temperature was concentrated under reduced pressure. The resulting solid was washed with hexane, and 12.0 g of 4-(2-propynyloxy)-3,5-dimethoxybenzoyl chloride was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003699B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-e1fef0b99fa8410aaef96e73c2a56890 |
| Source note | uspto-grants-2011_08 |