反应详情

To 100 ml of toluene were added 13.0 g of 4-(2-propynyloxy)-3,5-dimethoxybenzoic acid, 9.5 g of thionyl chloride and 50 mg of DMF, and the resulting mixture was heated under reflux for 3 hours. Thereafter, the reaction mixture which had been allowed to cool to near room temperature was concentrated under reduced pressure. The resulting solid was washed with hexane, and 12.0 g of 4-(2-propynyloxy)-3,5-dimethoxybenzoyl chloride was obtained.

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux for 3 hours
3. concentrationwas concentrated under reduced pressure
4. washThe resulting solid was washed with hexane