反应详情

To 50 ml of methanol were added 13.2 g of 2-propynyl 4-(2-propynyloxy)-3-methoxybenzoate and 40 ml of a 15% aqueous sodium hydroxide solution, and the resulting mixture was stirred at room temperature for 8 hours, and then at 50° C. for 2 hours. Thereafter, the reaction mixture which had been allowed to cool to near room temperature was added to hydrochloric acid to make the mixture acidic. The precipitated crystals were collected by filtration, and dried, and 12.0 g of 4-(2-propynyloxy)-3-methoxybenzoic acid was obtained.

1. waitat 50° C. for 2 hours
2. temperatureto cool to near room temperature
3. filtrationThe precipitated crystals were collected by filtration
4. customdried