Ethyl 2-(4-chloro-2-methoxyphenoxy)acetate → (4-Chloro-2-hydroxyphenoxy)acetic acid

HRID 1675601Notes

Reaction equation

HRID 1675601 reaction equation
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH2:7][C:8]([O:10]CC)=[O:9])=[C:4]([O:15]C)[CH:3]=1>Br>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([OH:15])[CH:3]=1

Participants

3

Reactant 1

HCID 11701508Ethyl 2-(4-chloro-2-methoxyphenoxy)acetate

Product 1

HCID 16748825(4-Chloro-2-hydroxyphenoxy)acetic acid

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

A mixture of the product from step (i) (2.7 g) in 48% aqueous hydrogen bromide (30 ml) was heated under reflux for 2 h. The solvent was evaporated, the residue washed with water and dried, yield 1.7 g.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 h
  3. customThe solvent was evaporated
  4. washthe residue washed with water
  5. customdried

Sources & evidence

ORD record
ord-542d1ec0fffa4e2da579595d4a701482
Source dataset
uspto-grants-2011_08
Patent number
US08003703B2

Reaction notes

Loading…