HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 11428225, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Fluoro-4-(methylsulphonyl)benzene | HCID 67994 | — |
| Reactant | 6-Chloro-2H-1,4-benzoxazin-3(4H)-one | HCID 309259 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 11428225 | HCID 11428225 | — |
Reaction Steps
Potassium carbonate (0.265 g) was added to a solution of the product from step (ii) (0.44 g) and 4-fluorophenyl methyl sulfone (0.331 g) in NMP (20 ml) and the mixture heated at is 120° C. for 16 h. The reaction was diluted with water and extracted with ethylacetate, the organics were dried and evaporated under reduced pressure. The residue was purified by reverse phase HPLC, yield 0.096 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003703B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-b39b1205488a47b2b331627851928a02 |
| Source note | uspto-grants-2011_08 |