Potassium Carbonate → HCID 11428225, compound

HRID 1675604Notes

Reaction equation

HRID 1675604 reaction equation
[C:1](=[O:4])([O-])[O-:2].[K+].[K+].[Cl:7][C:8]1[CH:9]=[CH:10][C:11]2[O:16][CH2:15][C:14](=O)[NH:13][C:12]=2[CH:18]=1.[CH3:19][S:20]([C:23]1[CH:28]=[CH:27]C(F)=[CH:25][CH:24]=1)(=[O:22])=[O:21]>CN1C(=O)CCC1.O>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([O:16][CH2:15][C:1]([OH:2])=[O:4])=[C:12]([NH:13][C:14]2[CH:27]=[CH:28][C:23]([S:20]([CH3:19])(=[O:22])=[O:21])=[CH:24][CH:25]=2)[CH:18]=1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 679941-Fluoro-4-(methylsulphonyl)benzeneHCID 3092596-Chloro-2H-1,4-benzoxazin-3(4H)-one

Product 1

HCID 11428225HCID 11428225, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Potassium carbonate (0.265 g) was added to a solution of the product from step (ii) (0.44 g) and 4-fluorophenyl methyl sulfone (0.331 g) in NMP (20 ml) and the mixture heated at is 120° C. for 16 h. The reaction was diluted with water and extracted with ethylacetate, the organics were dried and evaporated under reduced pressure. The residue was purified by reverse phase HPLC, yield 0.096 g.

Workup

  1. temperaturethe mixture heated
  2. extractionextracted with ethylacetate
  3. customthe organics were dried
  4. customevaporated under reduced pressure
  5. customThe residue was purified by reverse phase HPLC, yield 0.096 g

Sources & evidence

ORD record
ord-b39b1205488a47b2b331627851928a02
Source dataset
uspto-grants-2011_08
Patent number
US08003703B2

Reaction notes

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