1,2-Difluoro-4,5-dimethoxybenzene → 4,5-Difluoro-2-methoxyphenol

Participants

Reaction Conditions

Reaction Steps

Sodium thiomethoxide (0.4 g) was added to a solution of 1,2-difluoro-4,5-dimethoxybenzene (1.0 g) in DMF (10 ml) at RT, then heated at 100° C. for 4 h. A further 0.8 g of sodium thiomethoxide was added, the mixture heated for a further 2 h. The mixture was cooled, partitioned between ethylacetate/2M hydrochloric acid, the organics dried and evaporated under reduced pressure, yield 1.05 g

Provenance & Evidence