1,2-Difluoro-4,5-dimethoxybenzene → HCID 18687664, compound

HRID 1675611Notes

Reaction equation

HRID 1675611 reaction equation
C[S-].[Na+].[F:4][C:5]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13]C)=[CH:7][C:6]=1[F:15]>CN(C=O)C>[F:4][C:5]1[C:6]([F:15])=[CH:7][C:8]([OH:13])=[C:9]([O:11][CH3:12])[CH:10]=1

Participants

4

Reactant 2

HCID 8531751,2-Difluoro-4,5-dimethoxybenzeneHCID 4378561Sodium methanethiolate2×

Product 1

HCID 18687664HCID 18687664, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

Sodium thiomethoxide (0.4 g) was added to a solution of 1,2-difluoro-4,5-dimethoxybenzene (1.0 g) in DMF (10 ml) at RT, then heated at 100° C. for 4 h. A further 0.8 g of sodium thiomethoxide was added, the mixture heated for a further 2 h. The mixture was cooled, partitioned between ethylacetate/2M hydrochloric acid, the organics dried and evaporated under reduced pressure, yield 1.05 g

Workup

  1. temperaturethe mixture heated for a further 2 h
  2. temperatureThe mixture was cooled
  3. custompartitioned between ethylacetate/2M hydrochloric acid
  4. customthe organics dried
  5. customevaporated under reduced pressure, yield 1.05 g

Sources & evidence

ORD record
ord-ff9b2b92ded94c288010e1cf5a279e48
Source dataset
uspto-grants-2011_08
Patent number
US08003703B2

Reaction notes

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